This list is an attempt to document all B-sides and bonus tracks recorded by the band Weezer. The term "B-side" originally described additional songs included on the reverse sides of vinyl singles but, for the purposes of this list, also includes additional songs included on CD singles and certain EP releases. The term "bonus track", for the purposes of this list, includes tracks released as promotional bonuses or included on regional album variants.
Single-sided deafness (SSD) is a type of unilateral hearing loss where the reduction in hearing is so severe that your ear is considered to be non-functional or deaf. That is, a person has no or limited access to sound in that ear and may or may not benefit from hearing aid on that ear.
Sid Side B Complete Collection Rar
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Many people have some degree of hearing loss in one or both ears. Unilateral hearing loss can affect your ability to take part in conversations and activities. Infants born with unilateral hearing loss or single-sided deafness can get help from early speech and language therapies. Hearing specialists can determine the best treatments to help you hear better. Hearing assist devices may help.
Side A's eponymous debut album included their first hit single "Eva Marie" which paved the way for their illustrious recording career. Classic Side A songs such as "Windows of Our Souls" and "'Di Pa Huli" can be found on the album. The uptempo "'Di Pa Huli" catapulted the band into the mainstream. Instead of being written as "Side B", the B-side of their albums were written as "Side A too".
The objective of this technique is to enable redirects on the client side without confusing the user. Redirects are preferably implemented on the server side (see SVR1: Implementing automatic redirects on the server side instead of on the client side (SERVER)), but authors do not always have control over server-side technologies.
The Sycamore Library, a branch of the UNT Libraries housed in Sycamore Hall,is home to several physical collections including maps and posters, juvenilematerials, government documents, and business, political science, geography,and law materials. Our public spaces offer student computing services as wellas group and individual study spaces including two study rooms. Our dedicated full-time staff members and student assistants are available to provide access services and research assistance to patrons from UNT and beyond.
The Music Library supports the College of Music and the UNT community in providing outstanding collections of books about music, music journals, printed music, sound recordings from historic through contemporary formats, and music-related electronic databases. Special collections are a particular strength, emphasizing not only the many genres classified under Western art music and jazz, but also popular music and world music. Our dedicated full-time staff members and student assistants are available to provide access services and research assistance to patrons from UNT and beyond.
Collects and preserves rare and unique materials including books, oralhistories, university archives, historical manuscripts, maps, microfilm,photographs, art and artifacts. View exhibits and work with our collections bothonline or in the Sarah T. Hughes Reading Room.
Panendoscopy: This exam is done in the operating room after you are given drugs to make you sleep. The surgeon looks inside your nose, mouth, and throat and sometimes the esophagus (swallowing tube) and trachea (windpipe) through thin tubes called scopes and may take out pieces of tissue (biopsies) to be checked in the lab.
Barium swallow: For this test, x-rays are taken while you swallow a liquid with barium in it. Barium coats the inside surface of the mouth and throat and helps get a good picture. This test might be done if you are having trouble swallowing because it shows how your throat looks as you swallow.
Dental exam: Your dentist will probably do a complete exam and maybe some x-rays of your teeth and jaw before any radiation is given because radiation can damage the saliva (spit) glands and cause dry mouth. The dentist might also remove bad teeth to lower the chances of cavities and infection.
Quit smoking: If you smoke cigarettes or use chewing tobacco, your doctor might talk to you about quitting all tobacco products before starting treatment. Smoking while getting cancer treatment can cause problems such as poor wound healing after surgery, more side effects from chemo, and a higher chance of infection.
Any type of surgery can have risks and side effects. Ask the doctor what you can expect. If you have problems, let your doctors know. Doctors who treat people with oral cavity and oropharyngeal cancers should be able to help you with any problems that come up.
Chemo can make you feel very tired, sick to your stomach, and cause your hair to fall out. But most of these problems go away after treatment ends. Other side effects like hearing problems or nerve damage can last a long time.
Side effects of targeted drug therapy depend on which drug is used. These drugs can make you feel sick to your stomach and cause low blood counts. They can also cause skin changes of the hands and feet. These side effects usually go away after treatment ends.
Immunotherapy can cause many different side effects depending on which drug is used. These drugs may make you feel tired, sick to your stomach, or cause a rash. Most of these problems go away after treatment ends.
Abstract Retinoic acid receptors (RARs) and retinoid X receptors(RXRs) are members of the nuclear receptor superfamily whose effects on cellgrowth and survival can be modulated therapeutically by small-moleculeligands. Although compounds that target these receptors are powerfulanticancer drugs, their use is limited by toxicity. An improved understandingof the structural biology of RXRs and RARs and recent advances in thechemical synthesis of modified retinoid and rexinoid ligands should enablethe rational design of more selective agents that might overcome suchproblems. Here, we review structural data for RXRs and RARs, discussstrategies in the design of selective RXR and RAR modulators, and considerlessons that can be learned for the design of selective nuclear-receptormodulators in general.
Structural principles of agonist action. RARs have the modularstructure common to all NRs, with an N-terminal activation function (AF-1), acentral DBD and a C-terminal LBD (FIG. 1). The multifunctional LBD isresponsible for ligand binding and dimerization and contains aligand-dependent activation function (AF-2), which in molecular termscorresponds to co-regulator interaction surfaces that can be modulated (forreviews and references see REF. 2). The LBD of all NRs is a single proteindomain organized in a primarily helical scaffold--termed an antiparallel[alpha]-helical sandwich --of 11-13 helices arranged in three layers (9). Forretinoid receptors, the twelve [alpha]-helices (Hs) and the short (S1-S2)[beta]-turn are arranged in a particular manner: H1-H3 occupy one face, H4,H5, S1-S2, H8 and H9 comprise the central layer, and H6, H7 and H10constitute the second face (FIGS 1,2). In all agonist-bound (holo) structuresof RARs and RXRs that have been solved so far (Supplementary information S1(table)), the ligands are stabilized through extensive van der waals contactsand by a network of ionic and hydrogen bonds involving their carboxylatemoiety, a conserved arginine in H5, and water molecules. The compactstructure of the liganded ligand-binding pocket (LBP) is sealed by H12 on oneside and by H5 on the other side.
The chemistry toolbox for retinoids and rexinoids The buildingblocks. Three regions in the retinoid skeleton are generally distinguished tofacilitate structural comparison: the hydrophobic part, the polar region(usually a carboxylic acid to establish an ionic bridge with an arginine inthe receptor LBP) and the central polyene connector or linker (FIG. 5).Skeletal modifications, most notably in the hydrophobic and central regions,are directed towards increasing the retinoid stability (as the nativeretinoids show acid, base, thermal and photochemical sensitivity). Mostoften, part of the polyene side chain is constrained in a cyclic system oftwo or more aromatic rings (locked retinoids or arotinoids (27)), therebyincreasing its chemical stability. Additional substituents are added to blockthe allylic C4-position, which prevent metabolic oxidative degradation (FIG.5). The retinoid building blocks representative of the large collection ofsynthetic retinoids reported to date are summarized in Supplementaryinformation S5 (box) (analogues of all-trans RA; ATRA) and Supplementaryinformation S6 (box) (analogues of 9-cis RA). The hydrophobic region is themotif of the greatest structural diversity, built in particular aroundnaphthalene and phenanthrene cores, and their heterocyclic derivatives.
Structure-guided design of selective ret(x)inoids Selectivity I:RAR isotype-specific agonists. Of all the residues lining the LBPs, onlythree diverge among the RAR isotypes (FIG. 6a; see Supplementary informationS10 (movie)), and LBP swaps confirmed the role of these residues in isotypespecification. RAR[alpha] and RAR[beta] differ by just one residue in H3,whereas two residues (in H5 and H11) diverge in the LBPs of RAR[beta] andRAR[gamma]. Note that H3/H5 interact with the polyene side chain, whereas H11contacts the hydrophobic ring. Based on a great number of structural andfunctional data (Supplementary information S11 (table)), guidelines for thesynthesis of isotype-selective RAR ligands, both agonists and antagonists,have been established (TABLE 1; for details and references see REF. 29).
RXR versus RAR. In contrast to the linear I-shape of the RARpocket with a bulge on one end, which can accommodate easily ATRA and9-cis-RA, with the latter adopting a trans-like conformation31 (FIG. 6b), RXRfeatures an L-shaped pocket with a shorter maximal length. TABLE 1 shows thecharacteristics of the RXR ligand binding site that explain the selectivityof 9-cis RA over ATRA. The restrictive shape of the RXR LBP, which requires asharp bend or a twist of the polyene side chain in the retinoid skeleton toallow binding, is perfectly adapted to accommodate the 9-cis isomer andprecludes ATRA binding. 2ff7e9595c
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